Composition:
Pioglitazone 15 mg + metformin 500 mg tablets
Mechanism of Action:
Pioglitazone
Pioglitazone exerts its pharmacological effects by acting as a potent and highly selective agonist for the peroxisome proliferators activated receptor-gamma. Activation of these receptors promotes the transcription of several insulin responsive genes that help control lipid metabolism and glucose levels. It also reduces the insulin resistance in the periphery and in the liver of patients.
Metformin
Metformin decreases hepatic glucose production and intestinal absorption of glucose while improving insulin sensitivity.
Indications:
- In the treatment of type II diabetes mellitus
- Used when one anti-diabetes drug fails to control blood glucose level. This combination effectively reduces insulin resistance both at liver and peripheral tissues.
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